Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

  • Chem Commun (Camb). 2013 Nov 14;49(88):10361-3. doi: 10.1039/c3cc45802d.
Hushan Yuan  1 ,  Hoonsung Cho ,  Howard H Chen ,  Marcelo Panagia ,  David E Sosnovik ,  Lee Josephson
Affiliations
  • 1. Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. [email protected].
PMID: 24072060 DOI: 10.1039/c3cc45802d
Abstract

Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are a new class of spectrally variable, mitochondrially targeted probes, with an [(18)F] labeling option which, when enabled, allows imaging of a cardiac perfusion deficit using PET/CT.

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