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  2. Py-BODIPY-NHS ester

Py-BODIPY-NHS ester 

Cat. No.: HY-D1106 Purity: 98.05%
Handling Instructions

Py-BODIPY-NHS ester is a cell-permeable and fluorescent energy transfer probe. Py-BODIPY-NHS ester tracer yields strong cellular engagement and proves to be optimal for MET kinase. The live-cell energy transfer technique can perform a broad-coverage, quantitative analysis of intracellular kinase target engagement.

For research use only. We do not sell to patients.

Py-BODIPY-NHS ester Chemical Structure

Py-BODIPY-NHS ester Chemical Structure

CAS No. : 201998-61-0

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Py-BODIPY-NHS ester is a cell-permeable and fluorescent energy transfer probe. Py-BODIPY-NHS ester tracer yields strong cellular engagement and proves to be optimal for MET kinase. The live-cell energy transfer technique can perform a broad-coverage, quantitative analysis of intracellular kinase target engagement[1][2].

In Vitro

Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are a new class of spectrally variable, mitochondrially targeted probes. NanoBRET 590 SE (compound 2b) is synthesized by reacting the TPP-amine with NHS esters of BODIPY red[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.18

Formula

C₂₀H₁₇BF₂N₄O₄

CAS No.

201998-61-0

SMILES

[F-][B+3]1([N]2=C(C3=CC=CN3)C=CC2=CC4=CC=C(CCC(ON(C5=O)C(CC5)=O)=O)[N-]14)[F-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (33.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3464 mL 11.7321 mL 23.4643 mL
5 mM 0.4693 mL 2.3464 mL 4.6929 mL
10 mM 0.2346 mL 1.1732 mL 2.3464 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (3.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.43 mg/mL (3.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Py-BODIPY-NHS esterOthersenergytransferprobefluorescentTriphenylphosphonium-fluorochromesTPP-fluorochromesInhibitorinhibitorinhibit

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Product Name:
Py-BODIPY-NHS ester
Cat. No.:
HY-D1106
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