Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion

  • Bull Exp Biol Med. 2013 Jun;155(2):245-8. doi: 10.1007/s10517-013-2124-2.
Yu V Dmitriev  1 ,  S M Minasian ,  E A Demchenko ,  M M Galagudza
Affiliations
  • 1. V. A. Almazov Federal Center of Heart, Blood, and Endocrinology, the Ministry of Health and Social Development of Russia, St. Petersburg, Russia. [email protected].
PMID: 24131001 DOI: 10.1007/s10517-013-2124-2
Abstract

The cardioprotective effects of Necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone.

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