Hepatoprotective triterpenoids and saponins of Schefflera kwangsiensis

  • Planta Med. 2014 Feb;80(2-3):215-22. doi: 10.1055/s-0033-1360179.
Yan Wang  1 ,  Chun-Lei Zhang  1 ,  Yan-Fei Liu  1 ,  Dong Liang  1 ,  Huan Luo  1 ,  Zhi-You Hao  1 ,  Ruo-Yun Chen  1 ,  De-Quan Yu  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
PMID: 24356907 DOI: 10.1055/s-0033-1360179
Abstract

Seven new triterpenoid saponins, schekwangsiensides A-G (1-7), and a new triterpenoid, schekwangsienin (8), together with nine known triterpenoids and saponins (9-17), were isolated from the aerial parts of Schefflera kwangsiensis. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 4, 8, 9, and 15 (10 µM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.

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