α-Glucosidase inhibitory activities of isoflavanones, isoflavones, and pterocarpans from Mucuna pruriens

  • Planta Med. 2014 May;80(7):604-8. doi: 10.1055/s-0034-1368427.
Tshewang Dendup  1 ,  Vilailak Prachyawarakorn  2 ,  Acharavadee Pansanit  2 ,  Chulabhorn Mahidol  1 ,  Somsak Ruchirawat  1 ,  Prasat Kittakoop  1
Affiliations
  • 1. Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand.
  • 2. Chulabhorn Research Institute, Bangkok, Thailand.
PMID: 24782227 DOI: 10.1055/s-0034-1368427
Abstract

Three new Isoflavanones (1-3) and thirteen known compounds (4-16) were isolated from the roots of Mucuna pruriens. The absolute configurations of Isoflavanones 1-3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, Isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent.

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