Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

  • Arch Pharm Res. 2015;38(5):677-82. doi: 10.1007/s12272-014-0432-3.
Hoang Viet Dung  1 ,  To Dao Cuong ,  Nguyen Minh Chinh ,  Do Quyen ,  Jeong Ah Kim ,  Jeong Su Byeon ,  Mi Hee Woo ,  Jae Sui Choi ,  Byung Sun Min
Affiliations
  • 1. Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam.
PMID: 25005067 DOI: 10.1007/s12272-014-0432-3
Abstract

A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

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