Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells

  • J Nat Med. 2015 Jul;69(3):421-6. doi: 10.1007/s11418-015-0898-4.
Kan'ichiro Ishiuchi  1 ,  Yasuhiro Kosuge ,  Hazuki Hamagami ,  Mayu Ozaki ,  Kumiko Ishige ,  Yoshihisa Ito ,  Susumu Kitanaka
Affiliations
  • 1. School of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi, Chiba, 274-8555, Japan.
PMID: 25794817 DOI: 10.1007/s11418-015-0898-4
Abstract

Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), juncusol (4), dehydrojuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11). The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.

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