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  4. Juncuenin B

Juncuenin B is a natural phenolic compound.

For research use only. We do not sell to patients.

Juncuenin B

Juncuenin B Chemical Structure

CAS No. : 1161681-20-4

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Juncuenin B Related Antibodies

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Description

Juncuenin B is a natural phenolic compound.

IC50 & Target

Caspase 3

 

In Vitro

Juncuenin B (10-100 µM; 24 h) induces concentration-dependent cytotoxicity and caspase-3-mediated apoptosis in HT22 mouse hippocampal cells[1].
Juncuenin B (0.1-30 µM; 72 h) exhibits antiproliferative activity against HeLa and A2780 cells (IC50 = 2.9 μM and 7.3 μM, respectively) and is inactive against NIH/3T3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Juncuenin B Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HT22 mouse hippocampal cells
Concentration: 10, 30 and 100 μM
Incubation Time: 24 h
Result: Induced a concentration-dependent decrease in MTT reduction with values of 96.3 ± 5.3% at 10 μM, 88.1 ± 2.6% at 30 μM, and 13.6 ± 2.4% at 100 μM relative to vehicle-treated cells.

Western Blot Analysis[1]

Cell Line: HT22 mouse hippocampal cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Induced cleavage of caspase-3.

Cell Proliferation Assay[2]

Cell Line: HeLa, A2780, NIH/3T3
Concentration: 0.1-30 μM
Incubation Time: 72 h
Result: Inhibited proliferation of HeLa cells with an IC₅₀ of 2.9 ± 0.5 μM, A2780 cells with an IC₅₀ of 7.3 ± 1.3 μM, and showed no significant activity against NIH/3T3 cells (IC₅₀ > 30 μM).
Molecular Weight

266.33

Formula

C18H18O2
CAS No.
SMILES

OC1=C(C)C2=C(C3=CC(O)=C(C)C(C=C)=C3CC2)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Juncuenin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Juncuenin B1161681-20-4Drug DerivativeDrug derivativecaspase-3cancerNIH/3T3A2780HT22HeLaapoptosisInhibitorinhibitorinhibit

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