Juncuenin B
Juncuenin B is a natural phenolic compound.
For research use only. We do not sell to patients.
- CAS No.: 1161681-20-4
- Formula: C18H18O2
- Molecular Weight:266.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
7.3 μM
Compound: Juncuenin B
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Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33064469] |
| HeLa | IC50 |
2.9 μM
Compound: Juncuenin B
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33064469] |
| MCF7 | IC50 |
11.7 μM
Compound: Juncuenin B
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33064469] |
| MDA-MB-231 | IC50 |
9.4 μM
Compound: Juncuenin B
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33064469] |
| NIH3T3 | IC50 |
>30 μM
Compound: Juncuenin B
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Antiproliferative activity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33064469] |
| RAW264.7 | IC50 |
4.9 μM
Compound: 18
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Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
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[PMID: 29280630] |
Juncuenin B (10-100 µM; 24 h) induces concentration-dependent cytotoxicity and caspase-3-mediated apoptosis in HT22 mouse hippocampal cells[1].
Juncuenin B (0.1-30 µM; 72 h) exhibits antiproliferative activity against HeLa and A2780 cells (IC50 = 2.9 μM and 7.3 μM, respectively) and is inactive against NIH/3T3 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT22 mouse hippocampal cells
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Concentration:10, 30 and 100 μM
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Incubation Time:24 h
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Result:Induced a concentration-dependent decrease in MTT reduction with values of 96.3 ± 5.3% at 10 μM, 88.1 ± 2.6% at 30 μM, and 13.6 ± 2.4% at 100 μM relative to vehicle-treated cells.
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Cell Line:HT22 mouse hippocampal cells
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Concentration:100 μM
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Incubation Time:24 h
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Result:Induced cleavage of caspase-3.
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Cell Line:HeLa, A2780, NIH/3T3
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Concentration:0.1-30 μM
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Incubation Time:72 h
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Result:Inhibited proliferation of HeLa cells with an IC₅₀ of 2.9 ± 0.5 μM, A2780 cells with an IC₅₀ of 7.3 ± 1.3 μM, and showed no significant activity against NIH/3T3 cells (IC₅₀ > 30 μM).
Chemical Information
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CAS No. 1161681-20-4
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Molecular Weight 266.33
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Formula C18H18O2
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SMILES
OC1=C(C)C2=C(C3=CC(O)=C(C)C(C=C)=C3CC2)C=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ishiuchi K, et al. Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells. J Nat Med. 2015;69(3):421-426. [Content Brief]
[2]. Bús C, et al. Oxidized Juncuenin B Analogues with Increased Antiproliferative Activity on Human Adherent Cell Lines: Semisynthesis and Biological Evaluation. J Nat Prod. 2020;83(11):3250-3261. [Content Brief]
[3]. Sun L, et al. Anxiolytic effect of a novel 9,10-dihydrophenanthrene, juncuenin H, is associated with metabolic changes in cortical serotonin/dopamine levels in mice. Fitoterapia. 2019;134:165-171. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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