The emerging role of CaMKII in cancer

  • Oncotarget. 2015 May 20;6(14):11725-34. doi: 10.18632/oncotarget.3955.
Yan-yang Wang  1  2 ,  Ren Zhao  1  2 ,  Hong Zhe  1  2
Affiliations
  • 1. Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
  • 2. Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia, China.
PMID: 25961153 DOI: 10.18632/oncotarget.3955
Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of Cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of Cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for Cancer diagnosis and treatment.

Keywords
Ca2+/calmodulin-dependent protein kinase II (CaMKII); CaMKII inhibitor; cancer; cell cycle; therapeutic target.
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