Studies of MR 889, a new synthetic proteinase inhibitor

  • Biochem Biophys Res Commun. 1989 Dec 15;165(2):568-73. doi: 10.1016/s0006-291x(89)80004-x.
M Luisetti  1 ,  P D Piccioni ,  M Donnini ,  V Peona ,  E Pozzi ,  C Grassi
Affiliations
  • 1. Istituto di Tisiologia e Malattie Respiratorie dell'Università, IRCCS Policlinico San Matteo, Pavia, Italy.
PMID: 2597145 DOI: 10.1016/s0006-291x(89)80004-x
Abstract

We investigated the proteinase inhibitory activity of MR 889, a thiolactic acid derivative. It is able to in vitro inhibit at low concentration (10(-5),10(-6)M) the activity of porcine pancreatic Elastase, human neutrophil Elastase and bovine chymotrypsin. In addition, MR 889 is able to inhibit the residual activity of alpha 2-macroglobulin-trapped human neutrophil Elastase, paralleling the efficacy of phenylmethylsufonylfluoride. Finally, MR 889 has been shown to in vitro reduce the burden of elastase- and chymotrypsin-like activity found in sputum sol-phases of patients admitted for chronic bronchitis exacerbation.

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