Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii

  • Steroids. 2015 Dec;104:182-8. doi: 10.1016/j.steroids.2015.09.012.
Henrik Harms  1 ,  Stefan Kehraus  1 ,  Damun Nesaei-Mosaferan  1 ,  Peter Hufendieck  1 ,  Laurent Meijer  2 ,  Gabriele M König  3
Affiliations
  • 1. Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
  • 2. ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, France.
  • 3. Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany. Electronic address: [email protected].
PMID: 26440473 DOI: 10.1016/j.steroids.2015.09.012
Abstract

The ascomycete Dichotomomyces cejpii was isolated from the marine Sponge Callyspongia cf. C. flammea. Three new Steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from Fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease.

Keywords
Alzheimer’s disease; Dichotomomyces cejpii; Ergosterol derivatives.
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