A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

  • Chem Commun (Camb). 2016 Feb 7;52(11):2296-9. doi: 10.1039/c5cc09998f.
Yaping Liu  1 ,  Huilong Ma  1 ,  Liangwei Zhang  1 ,  Yajing Cui  1 ,  Xiaoting Liu  1 ,  Jianguo Fang  1
Affiliations
  • 1. State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. [email protected].
PMID: 26725656 DOI: 10.1039/c5cc09998f
Abstract

The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

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