Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

  • ACS Appl Mater Interfaces. 2016 May 18;8(19):12039-47. doi: 10.1021/acsami.6b02721.
Wenbo Hu  1 ,  Hengheng Ma  1 ,  Bing Hou  1 ,  Hui Zhao  1 ,  Yu Ji  1 ,  Rongcui Jiang  1 ,  Xiaoming Hu  1 ,  Xiaomei Lu  2 ,  Lei Zhang  1 ,  Yufu Tang  1 ,  Quli Fan  1 ,  Wei Huang  2
Affiliations
  • 1. Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications , Nanjing 210023, China.
  • 2. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech) , Nanjing 211816, China.
PMID: 27123534 DOI: 10.1021/acsami.6b02721
Abstract

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against Cancer cells under NIR light.

Keywords
lysosome-targeting; near-infrared absorption; photoacoustic imaging; photodynamic therapy; theranostic nanoparticles.
Products