In Vitro Activity of Isavuconazole against Rasamsonia Species

  • Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891. doi: 10.1128/AAC.00742-16.
J Steinmann  1 ,  S Dittmer  2 ,  J Houbraken  3 ,  J Buer  2 ,  P-M Rath  2
Affiliations
  • 1. Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany [email protected].
  • 2. Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • 3. CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
PMID: 27527087 DOI: 10.1128/AAC.00742-16
Abstract

The in vitro susceptibilities to the novel triazole isavuconazole and six other Antifungal agents of a large collection of Rasamsonia isolates (n = 47) belonging to seven species were determined. Isavuconazole and voriconazole had no in vitro activity (MIC, >32 mg/liter) against isolates of the Rasamsonia argillacea species complex. The echinocandins were the most potent Antifungal drugs against all of the isolates tested (minimum effective concentration, ≤0.19 mg/liter).

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