Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

  • Molecules. 2016 Aug 29;21(9):1146. doi: 10.3390/molecules21091146.
Dongsheng Fan  1 ,  Guo-Yuan Zhu  2 ,  Ting Li  3 ,  Zhi-Hong Jiang  4 ,  Li-Ping Bai  5
Affiliations
  • 1. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. [email protected].
  • 2. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. [email protected].
  • 3. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. [email protected].
  • 4. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. [email protected].
  • 5. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. [email protected].
PMID: 27589701 DOI: 10.3390/molecules21091146
Abstract

Two new dimacrolide sesquiterpene Pyridine Alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3'-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Keywords
Tripterygium regelii; anti-inflammation; dimacrolide sesquiterpene pyridine alkaloids.
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