Three new drimane sesquiterpenoids from cultures of the fungus Penicillium sp

  • J Asian Nat Prod Res. 2017 Aug;19(8):780-785. doi: 10.1080/10286020.2016.1261830.
Jian-Hai Ding  1 ,  Zhang-Gui Ding  2 ,  Wei-Xun Chunyu  2 ,  Jiang-Yuan Zhao  2 ,  Hai-Bin Wang  1 ,  Shi-Wei Liu  1 ,  Fei Wang  3
Affiliations
  • 1. a Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering , Ningxia Normal University , Guyuan 756000 , China.
  • 2. b Key Laboratory for Microbial Resources, Ministry of Education , Yunnan Institute of Microbiology, Yunnan University , Kunming 650091 , China.
  • 3. c BioBioPha Co., Ltd. , Kunming 650201 , China.
PMID: 27892687 DOI: 10.1080/10286020.2016.1261830
Abstract

Three new drimane sesquiterpenoids, 12-hydroxyalbrassitriol (1), drim-8(12)-en-6β,7α, 9α,11-tetraol (2), and drim-68(12)-dien-9α,11-diol (3), along with one known analog albrassitriol (4), were isolated from cultures of the tin mine tailings-associated fungus Penicillium sp. The new structures were determined on the basis of extensive spectroscopic analyses. All compounds were tested for their cytotoxicities against five human Cancer cell lines.

Keywords
Penicillium sp.; cytotoxicities; drimane sesquiterpenoids; fungus.
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