Diterpenoids and Lignans from Cephalotaxus fortunei

  • J Nat Prod. 2017 Feb 24;80(2):356-362. doi: 10.1021/acs.jnatprod.6b00802.
Jin-Xin Zhao  1 ,  Yao-Yue Fan  1 ,  Jin-Biao Xu  1 ,  Li-She Gan  2 ,  Cheng-Hui Xu  1 ,  Jian Ding  1 ,  Jian-Min Yue  1
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2. College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310058, People's Republic of China.
PMID: 28139925 DOI: 10.1021/acs.jnatprod.6b00802
Abstract

Five new Diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type Diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new Lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) by X-ray crystallographic data. Compounds 3 and 4 are the first examples of 17-nor-cephalotane-type Diterpenoids that are likely the biosynthesis precursors of the co-occurring troponoids (e.g., 1, 2, and 9). Compound 1 exhibited cytotoxic activities against HL-60 and A-549 cells with IC50 values of 0.77 ± 0.05 and 1.129 ± 0.057 μM, respectively.