Two new monoterpenoid indole alkaloids from Alstonia rostrata

  • Nat Prod Res. 2018 Apr;32(7):844-848. doi: 10.1080/14786419.2017.1360886.
Yu-Xi Yuan  1  2 ,  Feng Guo  2 ,  Hong-Ping He  1 ,  Yu Zhang  1  2 ,  Xiao-Jiang Hao  1  2
Affiliations
  • 1. a Yunnan University of Traditional Chinese Medicine , Kunming , China.
  • 2. b State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.
PMID: 28768429 DOI: 10.1080/14786419.2017.1360886
Abstract

Two new Indole Alkaloids, winphyllines A (1) and B (4), along with four known Alkaloids, Nb-demethylechitamine (2), 17-O-acetylnorechitamine (3), 12-methoxyechitamidine (5), and N(4)-demethylastogustine (6), were isolated from the methanol extract of the twigs of Alstonia rostrata. The structures of 1 and 4 were elucidated by means of HRMS and NMR spectroscopic methods. The in vitro cytotoxic activity of the isolated Alkaloids against several human Cancer cell lines was evaluated.

Keywords
Alstonia rostrata; Apocynaceae; monoterpene indole alkaloid.
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