Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis

  • J Nat Prod. 2017 Dec 22;80(12):3103-3111. doi: 10.1021/acs.jnatprod.6b01127.
Xian-Sheng Ye  1  2 ,  Jun He  3 ,  Yung-Chi Cheng  4 ,  Lei Zhang  5 ,  Hao-Yi Qiao  1 ,  Xue-Ge Pan  1 ,  Jia Zhang  1 ,  Shu-Na Liu  1 ,  Wei-Ku Zhang  2 ,  Jie-Kun Xu  1
Affiliations
  • 1. School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
  • 2. Institute of Clinical Medical Sciences, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
  • 3. Department of Pharmacy, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
  • 4. Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520, United States.
  • 5. Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University , Beijing 100038, People's Republic of China.
PMID: 29140705 DOI: 10.1021/acs.jnatprod.6b01127
Abstract

Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.

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