Responses in reproductive organs, steroid hormones and CYP450 enzymes in female Mongolian gerbil (Meriones unguiculatus) over time after quinestrol treatment

  • Pestic Biochem Physiol. 2017 Nov:143:122-126. doi: 10.1016/j.pestbp.2017.08.008.
Qian-Qian Su  1 ,  Yi Chen  1 ,  Jiao Qin  1 ,  Tong-Liang Wang  2 ,  De-Hua Wang  3 ,  Quan-Sheng Liu  4
Affiliations
  • 1. Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, 510260 Guangzhou, China.
  • 2. College of Life Science, Hainan Normal University, 571158 Haikou, China; State Key Laboratory of Integrated Management of Pest Insect and Rodents, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
  • 3. State Key Laboratory of Integrated Management of Pest Insect and Rodents, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
  • 4. Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, 510260 Guangzhou, China. Electronic address: [email protected].
PMID: 29183580 DOI: 10.1016/j.pestbp.2017.08.008
Abstract

The aim of this study was to assess the effects and reversibility of the synthetic estrogen compound, quinestrol, on the reproductive organs, steroid Hormones, and drug-metabolizing Enzymes CYP3A4 and CYP1A2 in liver and kidney over time after two quinestrol treatments in female Mongolian gerbils (Meriones unguiculatus). Female gerbils were treated with 4mg/kg quinestrol (9 gerbils/group, 3 treated group) (1 control group, 0mg/kg) for 3days and treated again after 25days. Animals were killed for collection of samples at 5, 10 and 15days after the second treatment ending. Two interval quinestrol treatments significantly increased uterine weight, with trend of increase over time, but no change could be detected in ovarian weights. Quinestrol treatment increased progesterone and estradiol levels, both with trend of decline over time. Quinestrol increased liver and kidney weights and total enzyme content of CYP3A4 and CYP1A2, with trend of decline over time. On the basis of reversible changes of detoxification Enzymes or organs, interval quinestrol treatment effectively and reversibly influenced the reproductive hormone and organ to some extent.

Keywords
CYP450 enzymes; Fertility control; Gerbils; Quinestrol; Reversibility.
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