Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes

  • Bioorg Med Chem Lett. 2018 Feb 1;28(3):330-333. doi: 10.1016/j.bmcl.2017.12.045.
Jun-Jun Qin  1 ,  Ze-Min Lin  2 ,  Yan-Sheng Xu  2 ,  Ji-Wen Ren  3 ,  Jian-Ping Zuo  4 ,  Wei-Min Zhao  5
Affiliations
  • 1. Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
  • 2. Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201210, People's Republic of China.
  • 3. Gansu Forestry Technological College, No. 58 Mapaoquan Road, Tianshui, Gansu 741020, People's Republic of China.
  • 4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. Electronic address: [email protected].
  • 5. Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. Electronic address: [email protected].
PMID: 29292227 DOI: 10.1016/j.bmcl.2017.12.045
Abstract

Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (1-4), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (1-4) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A.

Keywords
Immunosuppression; Periploca chrysantha; Pregnane glycosides; Spiroorthoester group.