Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators

  • ACS Med Chem Lett. 2018 Dec 3;9(12):1156-1159. doi: 10.1021/acsmedchemlett.8b00566.
Nikunj M Shukla  1 ,  Michael Chan  1 ,  Tomoko Hayashi  1 ,  Dennis A Carson  1 ,  Howard B Cottam  1
Affiliations
  • 1. Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0695, United States.
PMID: 30613317 DOI: 10.1021/acsmedchemlett.8b00566
Abstract

Activation of Toll-like receptors (TLRs) located on immune cells leads to induction of immune responses that can be useful in vaccines for infectious diseases, Cancer Immunotherapy, and autoimmune diseases. Novel TLR signaling pathway modulators can further enhance the efficacy of TLR ligands.

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