Highly Modified Lanostane Triterpenes from Fruiting Bodies of the Basidiomycete Tomophagus sp

  • J Nat Prod. 2019 May 24;82(5):1165-1176. doi: 10.1021/acs.jnatprod.8b00869.
Masahiko Isaka  1 ,  Panida Chinthanom  1 ,  Tuksaporn Thummarukcharoen  1 ,  Thitiya Boonpratuang  1 ,  Wilunda Choowong  1
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology (BIOTEC) , 113 Thailand Science Park, Phaholyothin Road , Klong Luang , Pathumthani 12120 , Thailand.
PMID: 30983350 DOI: 10.1021/acs.jnatprod.8b00869
Abstract

Thirty-one highly modified lanostanes (1-31), together with 19 known compounds (32-50), were isolated from fruiting bodies of the wood-rot basidiomycete Tomophagus sp. The structures were elucidated by analyses of HRMS and NMR spectroscopic data. The present work demonstrates the high structural diversity of modified lanostane triterpenoids from Tomophagus. This paper also discusses structural revisions of several known derivatives. Some of the isolated compounds exhibited moderate antimalarial activity against Plasmodium falciparum K1 (IC50 5.1-19 μM).