Bishomoscalarane Sesterterpenoids from the Sponge Dysidea granulosa Collected in the South China Sea

  • J Nat Prod. 2020 Feb 28;83(2):516-523. doi: 10.1021/acs.jnatprod.9b01202.
Qi Wang  1  2 ,  Yanting Sun  1  2 ,  Lin Yang  1  2 ,  Xiangchao Luo  1  2 ,  Nicole J de Voogd  3 ,  Xuli Tang  4 ,  Pinglin Li  1  2 ,  Guoqiang Li  1  2
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.
  • 2. Laboratory of Marine Drugs and Biological Products , National Laboratory for Marine Science and Technology , Qingdao 266235 , People's Republic of China.
  • 3. National Museum of Natural History , PO Box 9517, 2300 RA Leiden , The Netherlands.
  • 4. College of Chemistry and Chemical Engineering , Ocean University of China , Qingdao 266100 , People's Republic of China.
PMID: 31990554 DOI: 10.1021/acs.jnatprod.9b01202
Abstract

Granulosane A (1), a new C27 bishomoscalarane sesterterpenoid with a rare 6/6/6/8 tetracyclic skeleton, together with eight additional new C27 bishomoscalarane sesterterpenes (2, 8-14) and five new C26 20,24-bishomo-25-norscalarane sesterterpenes (3-7), were isolated from the marine Sponge Dysidea granulosa collected in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum chemical calculation methods. Compound 4 showed antiproliferative activities against two Cancer cell lines.

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