Resorcylic Acid Lactones from an Ilyonectria sp

  • J Nat Prod. 2020 May 22;83(5):1505-1514. doi: 10.1021/acs.jnatprod.9b01167.
Jia Zhou  1 ,  Ying Gao  1 ,  Jin-Ling Chang  1 ,  Heng-Yi Yu  2 ,  Juan Chen  1 ,  Ming Zhou  1 ,  Xiang-Gao Meng  3 ,  Han-Li Ruan  1
Affiliations
  • 1. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
  • 2. Department of Pharmacy, Tongji Hospital Affiliated Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • 3. College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
PMID: 32323537 DOI: 10.1021/acs.jnatprod.9b01167
Abstract

Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (1a, 1b and 2), eight new 14-membered RALs (3-10), and one new 12-membered RAL (11), along with five known 14-membered RALs (12-16), were identified from the fermentation of the soil-derived fungus Ilyonectria sp. sb65. Their structures were established by detailed analyses of 1D and 2D NMR, HRESIMS, and X-ray diffraction crystallography. All new compounds were evaluated for their cytotoxic effects against three human Cancer cell lines, along with their potential as TRAIL sensitizers in TRAIL-resistant A549 human lung adenocarcinoma cells and their in vitro immunosuppressive effects against ConA-induced T-cell and LPS-induced B-cell proliferation.