Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with Echinococcus granulosus

  • Exp Parasitol. 2020 Aug;215:107917. doi: 10.1016/j.exppara.2020.107917.
Xiaojing Zhou  1 ,  Wen Wang  2 ,  Fang Cui  2 ,  Chunli Shi  2 ,  Xiaoping Gao  3 ,  Jiaxin Ouyang  2 ,  Yuxin Wang  4 ,  Atsushi Nagai  5 ,  Wei Zhao  6 ,  Mei Yin  7 ,  Jiaqing Zhao  8
Affiliations
  • 1. College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, China; Department of Neurology, Shimane University Faculty of Medicine, Izumo, 6938501, Japan.
  • 2. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
  • 3. Department of Otorhinolaryngology-Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
  • 4. College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, China.
  • 5. Department of Neurology, Shimane University Faculty of Medicine, Izumo, 6938501, Japan.
  • 6. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China; Center of Scientific Technology, Ningxia Medical University, Yinchuan, 750004, China.
  • 7. Cardiovascular Hospital Cardiovascular Hospital, General Hospital of Ningxia Medical University, Yinchuan, 750004, China. Electronic address: [email protected].
  • 8. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China; Center of Scientific Technology, Ningxia Medical University, Yinchuan, 750004, China. Electronic address: [email protected].
PMID: 32446699 DOI: 10.1016/j.exppara.2020.107917
Abstract

Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus Infection.

Keywords
Echinococcus granulosus; Immunosuppressive function; Myeloid-derived suppressor cells (MDSCs).
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