Toxicological alert: Exposure to glycidyl methacrylate and cancer risk

  • Toxicol Ind Health. 2020 Dec;36(12):937-939. doi: 10.1177/0748233720957816.
Bruno Jose Dumêt Fernandes  1 ,  Ricardo David Couto  2
Affiliations
  • 1. Clinical Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, 495454Federal University of Bahia/UFBA, Salvador, Bahia, Brazil.
  • 2. Clinical Biochemistry Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, 495454Federal University of Bahia/UFBA, Salvador, Bahia, Brazil.
PMID: 33155520 DOI: 10.1177/0748233720957816
Abstract

Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and Polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although there were no available data on carcinogenicity of GMA, carcinogenic potential in the nasal cavity is highly expected. Further studies are needed to assess GMA exposure in humans. This study provides an alert of GMA human exposure and its genotoxic and carcinogenic potential.

Keywords
GMA exposure; Glycidyl methacrylate (CAS no. 106-91-2); carcinogenicity; genotoxicity; occupational health.
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