Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih

  • Nat Prod Res. 2022 Aug;36(15):3909-3916. doi: 10.1080/14786419.2021.1897125.
Man Yi  1 ,  Fan-Cheng Meng  1 ,  Shen-Yue Qu  1 ,  Jing-Xin Mao  1 ,  Guowei Wang  1 ,  Mingxing Liu  1 ,  Zhi-Hua Liao  2 ,  Min Chen  1
Affiliations
  • 1. College of Pharmaceutical Sciences, Southwest University, Chongqing, P.R. China.
  • 2. School of Life Sciences, Southwest University, Chongqing, P.R. China.
PMID: 33719777 DOI: 10.1080/14786419.2021.1897125
Abstract

Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known Lignans, erythro-(7S,8R)-guaiacyl-glycerol-β-O-4'-dihydroconiferyl ether (3), threo-(7R,​8R)-1-​(4-​hydroxy-​3-​methoxyphenyl)​-​2-{4-[(E)-​3-​hydroxy-​1-​propen​yl)​]-​2-​methoxyphenoxy}-1,​3-​propanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinsepiol (9), medioresinol (10), (+)-pinoresinol (11), 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane (12), cycloolivil (13), isolariciresinol (14) were isolated from Dolomiaea souliei (Franch.) C.Shih. Their structures were determined by UV, CD, HR-ESI-TOFMS, 1 D and 2 D NMR experiments. Their hepatoprotective effect against LPS-induced L-02 cells injury was also studied. Result revealed that compound 4 showed best protective effect on LPS-induced L-02 cells.

Keywords
Dolomiaea souliei (Franch.) C.Shih; neolignans; dolominol A; dolominol B; hepatoprotective effect.
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