It takes three to the DNA damage response tango

  • Mol Cell Oncol. 2021 Feb 8;8(2):1881395. doi: 10.1080/23723556.2021.1881395.
Sapir Schlam-Babayov  1 ,  Yael Ziv  1 ,  Yosef Shiloh  1
Affiliations
  • 1. The David and Inez Myers Laboratory of Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University School of Medicine, Tel Aviv, Israel.
PMID: 33860085 DOI: 10.1080/23723556.2021.1881395
Abstract

The DNA damage response is robustly activated by DNA double-strand breaks and controlled by three apical protein kinases of the PI3-kinase-related protein kinase (PIKK) family: ataxia-telangiectasia, mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK). Phosphoproteomic analysis reveals the relative share of these PIKKs in coordinating this network, and compensation by ATR and DNA-PK for ATM absence in the genetic disorder, ataxia-telangiectasia (A-T).

Keywords
ATM; Ataxia-telangiectasia; DNA damage response; PIKKs; phosphoproteomic.