An enzyme-responsive Gp1a-hydrogel for skin wound healing

  • J Biomater Appl. 2021 Oct;36(4):714-721. doi: 10.1177/08853282211012870.
Chunming Zhao  1 ,  Yangyi Dong  2 ,  Jialin Liu  2 ,  Hongxing Cai  2 ,  Zhouru Li  2 ,  Xiaoming Sun  2 ,  Wenjiang Yin  2 ,  Jingyuan Ma  2 ,  Hongmei Liu  3 ,  Shanshan Li  2
Affiliations
  • 1. Department of Human Anatomy, Xuzhou Medical University, Xuzhou, China.
  • 2. Jiangsu Medical Engineering Research Center of Gene Detection and Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, China.
  • 3. Institute of Nervous System Diseases, Xuzhou Medical University and Neurosurgery Department, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
PMID: 33906517 DOI: 10.1177/08853282211012870
Abstract

Faster recovery and fewer scars are ideal wound healing. We have demonstrated that the Cannabinoid Receptor 2 (CB2) agonist Gp1a is beneficial to skin wound healing, which inhibits inflammation and fibrogenesis while promoting re-epithelialization. However, the systemic administration is imprecise and overqualified for a local skin wound. Herein, we prepared Gp1a-gel using triglycerol monostearate (Tm) hydrogel and detected whether the Gp1a-gel worked effectively on mouse skin excision wounds. The results showed that Gp1a-gel might sustainably increase the CB2 for at least 8 days. It decreased inflammation and fibrogenesis while promoting wound enclosure and re-epithelialization. These results suggested Gp1a-gel may utilize as a potential formulation strategy to treat the skin wound.

Keywords
Gp1a; Wound repair; cannabinoid receptor 2; fibrogenesis; hydrogel; re-epithelialization.
Products