Construction of a novel asymmetric imidazole-cored AIE probe for ratiometric imaging of endogenous leucine aminopeptidase

  • Chem Commun (Camb). 2021 Jul 6;57(54):6608-6611. doi: 10.1039/d1cc01940f.
Xueyan Huang  1 ,  Qian Lei  1 ,  Shuai Huang  1 ,  Hongliang Zeng  2 ,  Bin Feng  1 ,  Qinghai Zeng  3 ,  Yibo Hu  3 ,  Wenbin Zeng  1
Affiliations
  • 1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, P. R. China. [email protected] [email protected] and Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha 410078, China.
  • 2. Hunan Academic of Chinese Medicine, Inst Chinese Mat Med, Changsha, P. R. China.
  • 3. Dermatological Department, 3rd Xiangya Hospital, Central South University, Changsha, 410078, P. R. China.
PMID: 34114574 DOI: 10.1039/d1cc01940f
Abstract

We report a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to image endogenous LAP for the first time. It offered good sensitivity and selectivity, and concomitantly, was applied successfully for real-time tracking of LAP in the cisplatin-induced Liver Injury zebrafish model.

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