Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

  • Hypertension. 2021 Sep;78(3):647-660. doi: 10.1161/HYPERTENSIONAHA.121.17177.
Yuhao Zhang   #  1 ,  Sheng-An Su   #  1 ,  Wudi Li  1 ,  Yuankun Ma  1 ,  Jian Shen  1 ,  Yaping Wang  2 ,  Yimin Shen  1 ,  Jian Chen  1 ,  Yongli Ji  1 ,  Yao Xie  1 ,  Hong Ma  1 ,  Meixiang Xiang  1
Affiliations
  • 1. From the Department of Cardiology (Y.Z., S.-a.S., W.L., Y.M., J.S., Y.S., J.C., Y.J., Y.X., H.M., M.X.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • 2. Department of Endocrinology (Y.W.), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • # Contributed equally.
PMID: 34333987 DOI: 10.1161/HYPERTENSIONAHA.121.17177
Abstract

[Figure: see text].

Keywords
calcineurin; calpain; fibrosis; homeostasis; mechanotransduction.
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