Hygromycin A in the Lymelight

  • Cell Host Microbe. 2021 Nov 10;29(11):1599-1601. doi: 10.1016/j.chom.2021.10.007.
Paul Michael Arnaboldi  1 ,  Sukanya Narasimhan  2
Affiliations
  • 1. Department of Microbiology and Immunology, New York Medical College, Valhalla NY10595, USA; Biopeptides, Corp., East Setauket, NY 11733, USA.
  • 2. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA. Electronic address: [email protected].
PMID: 34762823 DOI: 10.1016/j.chom.2021.10.007
Abstract

Lyme disease, which is caused by the spirochete Borrelia burgdorferi, is on the rise. Current treatment relies on broad-spectrum Antibiotics that perturb the gut microbiome. In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten Antibiotic, Hygromycin A, as a spirochete-specific Antibacterial that is conducive to gut health.

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