A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing

  • Carbohydr Polym. 2022 Feb 1:277:118871. doi: 10.1016/j.carbpol.2021.118871.
Jiawei Lu  1 ,  Yi Chen  2 ,  Meng Ding  3 ,  Xiaokun Fan  1 ,  Jiawei Hu  1 ,  Yihua Chen  3 ,  Jie Li  1 ,  Zhihan Li  4 ,  Wenyong Liu  4
Affiliations
  • 1. School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou, China; Hunan Provincial Key Laboratory of Comprehensive Utilization of Agricultural and Animal Husbandry Waste Resources, College of Urban and Environmental Sciences, Hunan University of Technology, Zhuzhou, China.
  • 2. School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou, China; Hunan Provincial Key Laboratory of Comprehensive Utilization of Agricultural and Animal Husbandry Waste Resources, College of Urban and Environmental Sciences, Hunan University of Technology, Zhuzhou, China. Electronic address: [email protected].
  • 3. Hunan Provincial Key Laboratory of Comprehensive Utilization of Agricultural and Animal Husbandry Waste Resources, College of Urban and Environmental Sciences, Hunan University of Technology, Zhuzhou, China.
  • 4. School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou, China; Hunan Provincial Key Laboratory of Biomass Fiber Functional Materials, Hunan University of Technology, Zhuzhou, China.
PMID: 34893276 DOI: 10.1016/j.carbpol.2021.118871
Abstract

In order to develop better wound dressings, a novel chitosan hydrogel (Cn-Nm gel) was designed and fabricated by using aldehyde-4-arm polyethylene glycol (4r-PEG-CHO) to crosslink the chitosan dissolved in alkaline solution, amino-4-arm polyethylene glycol (4r-PEG-NH2) was chosen as the additive simultaneously. The special dissolution technique and macromolecular crosslinking structure endows the Cn-Nm gels with better performance than that of gels prepared by acid dissolving method with micromolecule crosslinker. First, Cn-Nm gels own strong toughness with 500 kPa tensile strength and 1000% elongation, about 400% swelling ratio and fast water absorption rate. Second, about 300 kPa adhesive strength and strippability between the gels and skin is achieved. More importantly, Cn-Nm gels show nearly 100% Antibacterial rate towards Escherichia coli and Staphylococcus aureus. Excellent biocompatibility is also proved by the mouse fibroblasts tests. All of the performance makes this developed chitosan-based gel be the potential candidate as a wound dressing.

Keywords
Antibiotic property; Chitosan; Gels; Wound dressing.
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