7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production

  • Sci Rep. 2022 May 24;12(1):8760. doi: 10.1038/s41598-022-12695-3.
Hao Dong  1 ,  Chenjie Feng  1 ,  Xiyunyi Cai  2 ,  Yuanyuan Hao  1 ,  Xinyue Gu  3 ,  Lei Cai  4 ,  Shuting Wu  5 ,  Jiamin Chen  1 ,  Zhou Liu  5 ,  Wen Xie  1 ,  Xuanren Lu  5 ,  Hongfa Qian  1 ,  Yulin Liu  1 ,  Yiming Cao  1 ,  Junlin Zhu  1 ,  Jiayi Xu  1 ,  Yanjie Zhou  1 ,  Shuangyu Ma  5 ,  Sha Yang  1 ,  Yufeng Shi  1 ,  Haojiang Yu  1 ,  Minjie Shi  1 ,  Yurong Wang  6 ,  Harvest F Gu  6 ,  Lei Fan  7 ,  Liang Wu  8
Affiliations
  • 1. Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 2. School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 3. Department of Applied Mathematics and Statistics, The Johns Hopkins University, Baltimore, MD, 21218, USA.
  • 4. School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 5. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 6. School of Basic Medicine and Clinical Pharmacy, Center for Pathophysiology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
  • 7. Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210009, People's Republic of China. [email protected].
  • 8. Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. [email protected].
PMID: 35610286 DOI: 10.1038/s41598-022-12695-3
Abstract

7-Met, a derivative of soybean isoflavone, is a natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects of 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). 7-Met ameliorated FITC or OXZ-induced atopic dermatitis symptoms by decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced atopic dermatitis mice, 7-Met reduced Th1 cytokines production and regulated Th1/Th2 balance by downregulating the secretion of thymic stromal lymphopoietin (TSLP) via inactivation of the NF-κB pathway. In OXZ-induced atopic dermatitis, 7-Met functioned through the reduction of Th17 cytokine production. Our study showed that 7-Methoxyisoflavone alleviated atopic dermatitis by regulating multiple signaling pathways and downregulating chemokine production.

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