Recent developments in antimalarial activities of 4-aminoquinoline derivatives

  • Eur J Med Chem. 2023 Aug 5:256:115458. doi: 10.1016/j.ejmech.2023.115458.
Lekkala Ravindar  1 ,  Siti Aishah Hasbullah  1 ,  K P Rakesh  2 ,  Nurul Izzaty Hassan  3
Affiliations
  • 1. Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi, 43600, Selangor, Malaysia.
  • 2. Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • 3. Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi, 43600, Selangor, Malaysia. Electronic address: [email protected].
PMID: 37163950 DOI: 10.1016/j.ejmech.2023.115458
Abstract

Malaria is the fifth most lethal parasitic Infection in the world. Antimalarial medications have played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties have been incorporated into the creation of effective antimalarial drugs. The 4-aminoquinoline moiety is favoured in antimalarial drug discovery due to the diverse biological applications of its derivative. Since the 1960s, 4-aminoquinoline has been an important antimalarial drug due to its low toxicity, high tolerability, and rapid absorption after administration. This review focused on the antimalarial efficacy of the 4-aminoquinoline moiety hybridised with various heterocyclic scaffolds developed by scientists since 2018 against diverse Plasmodium clones. It could aid in the future development of more effective antimalarial agents.

Keywords
4-Aminoquinolines; Antimalarial potency; Malaria; Parasite; Plasmodium falciparum.