Caryophyllene Sesquiterpenes from a Chaetomium globosum Endophyte of the Canadian Medicinal Plant Empetrum nigrum

  • J Nat Prod. 2023 Jun 23;86(6):1615-1619. doi: 10.1021/acs.jnatprod.2c01159.
Nicholas J Morehouse  1 ,  Trevor N Clark  1 ,  Russell G Kerr  2  3  4 ,  John A Johnson  1 ,  Christopher A Gray  1  5
Affiliations
  • 1. Department of Biological Sciences, University of New Brunswick, 100 Tucker Park Road, Saint John, NB E2L 4L5, Canada.
  • 2. Nautilus Biosciences Canada Inc., 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
  • 3. Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
  • 4. Department of Biomedical Sciences, Atlantic Veterinary College, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
  • 5. Department of Chemistry, University of New Brunswick, 30 Dineen Drive, Fredericton, NB E3B 5A3, Canada.
PMID: 37267043 DOI: 10.1021/acs.jnatprod.2c01159
Abstract

Punctaporonins T (1) and U (2), new caryophyllene Sesquiterpenes, were isolated with three known punctaporonins, A (3), B (4), and C (5), from the endophytic fungus Chaetomium globosum (TC2-041). The structures and relative configurations of punctaporonins T and U were elucidated based on a combination of HRESIMS, 1D/2D NMR spectroscopic analysis, and X-ray diffraction analysis, while their absolute configuration is presumed to be consistent with the co-isolated 3-5 on biogenetic arguments. Compound 1 showed weak inhibitory activity against both Mycobacterium tuberculosis and Staphylococcus aureus.