PhpC modulates G-quadruplex-RNA landscapes in human cells

  • Chem Commun (Camb). 2024 Jan 4;60(4):424-427. doi: 10.1039/d3cc05155b.
Jérémie Mitteaux  1 ,  Sandy Raevens  1 ,  Zi Wang  2 ,  Marc Pirrotta  1 ,  Ibai E Valverde  1 ,  Robert H E Hudson  2 ,  David Monchaud  1
Affiliations
  • 1. Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), CNRS UMR 6302, 9, avenue Alain Savary, Dijon 21078, France. [email protected].
  • 2. Department of Chemistry, The University of Western Ontario, London, ON N6A 5B7, Canada.
PMID: 38086624 DOI: 10.1039/d3cc05155b
Abstract

Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.

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