Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism

  • Molecules. 2024 Feb 5;29(3):741. doi: 10.3390/molecules29030741.
Tongjia Ni  1 ,  Shuai Zhang  2 ,  Jia Rao  1 ,  Jiaqi Zhao  1 ,  Haiqi Huang  1 ,  Ying Liu  1 ,  Yue Ding  1 ,  Yaqian Liu  1 ,  Yuchi Ma  3 ,  Shoujun Zhang  4 ,  Yang Gao  5 ,  Liqian Shen  5 ,  Chuanbo Ding  1  3 ,  Yunpeng Sun  1
Affiliations
  • 1. College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China.
  • 2. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
  • 3. Jilin Aodong Health Technology Co., Ltd., Yanbian 133700, China.
  • 4. Jilin Aodong Yanbian Pharmaceutical Co., Ltd., Yanbian 133700, China.
  • 5. Jilin Jianwei Natural Biotechnology Co., Ltd., Linjiang 134600, China.
PMID: 38338482 DOI: 10.3390/molecules29030741
Abstract

Phlorizin, as a flavonoid from a wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1β/IKB-α/NF-KB signaling pathway. At the same time, it exerts its Antibacterial activity by reducing intracellular DNA agglutination, reducing intracellular protein and energy synthesis, and destroying intracellular metabolism. In addition, phlorizin also has various pharmacological effects such as Antiviral, antidiabetic, antitumor, and hepatoprotective effects. Based on domestic and foreign research reports, this article reviews the plant sources, extraction, and biological activities of phlorizin, providing a reference for improving the clinical application of phlorizin.

Keywords
biological activity; extraction and identification; mechanism; phlorizin.
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