Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging

  • Heliyon. 2024 Jul 9;10(15):e34321. doi: 10.1016/j.heliyon.2024.e34321.
Yu Fu  1 ,  Jun-Ling Xie  1 ,  Wan-Ting Zhang  2 ,  Xing-Liao Zhang  1 ,  Xin-Min Zhang  2 ,  Meng-Meng Xu  1 ,  Yao-Ting Han  2 ,  Rong-Qi Liu  2 ,  Guang-Ming Xie  1 ,  Jing Zhang  2  3 ,  Jun Zhang  1  3  4
Affiliations
  • 1. Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China.
  • 2. Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China.
  • 3. Tongji Lifeng Institute of Regenerative Medicine, Tongji University, Shanghai, 200092, China.
  • 4. Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200092, China.
PMID: 39144947 DOI: 10.1016/j.heliyon.2024.e34321
Abstract

Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some Antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos and Antioxidants plays a synergistic role in anti-photoaging. In cellular and 3D skin models, we showed that vitamin E (VE) and hADSC-Exos were optimal anti-photoaging combinations. In vivo, VE and hADSC-Exos increased skin tightening and elasticity in UVB-induced photoaging mice Combined treatment with VE and hADSC-Exos inhibited SIRT1/NF-κB pathway. These findings contribute to the understanding of hADSC-Exos in conjunction with other Antioxidants, thereby providing valuable insights for the future pharmaceutical and cosmetic industries.

Keywords
Anti-Photoaging; Antioxidants; Skin rejuvenation; Synergistic delivery; hADSC-Exos.
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