Migratory autolysosome disposal mitigates lysosome damage

  • J Cell Biol. 2024 Dec 2;223(12):e202403195. doi: 10.1083/jcb.202403195.
Takami Sho  1 ,  Ying Li  2 ,  Haifeng Jiao  1 ,  Li Yu  1
Affiliations
  • 1. State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Centre for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.
  • 2. Cryo-EM Facility of Tsinghua University, Branch of National Protein Science Facility, Tsinghua University , Beijing, China.
PMID: 39347717 DOI: 10.1083/jcb.202403195
Abstract

Lysosomes, essential for intracellular degradation and recycling, employ damage-control strategies such as lysophagy and membrane repair mechanisms to maintain functionality and cellular homeostasis. Our study unveils migratory autolysosome disposal (MAD), a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring Autophagy machinery, SNARE proteins, and cell migration. This mechanism, crucial for mitigating lysosomal damage, underscores the role of cell migration in lysosome damage control and facilitates the release of small extracellular vesicles, highlighting the intricate relationship between cell migration, organelle quality control, and extracellular vesicle release.

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