TRPV2 Regulates Function of Human Neutrophil Granulocytes

  • FASEB J. 2025 Sep 30;39(18):e71052. doi: 10.1096/fj.202501585RR.
Anna S Heinemann  1 ,  Tabea C Fricke  1 ,  Christine Herzog  1 ,  Frank G Echtermeyer  1 ,  Andreas Leffler  1
Affiliations
  • 1. Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
PMID: 40948391 DOI: 10.1096/fj.202501585RR
Abstract

Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.

Keywords
TRPV2; cytokine; innate immunity; migration; neutrophils.
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