Four new isoquinoline alkaloids from Dactylicapnos lichiangensis and their anti-inflammatory activity

  • Fitoterapia. 2025 Sep 13:187:106868. doi: 10.1016/j.fitote.2025.106868.
Jing Wu  1 ,  Xin-Yu Liu  1 ,  Feng Wei  1 ,  Xiang-Hai Cai  2
Affiliations
  • 1. Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
  • 2. Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: [email protected].
PMID: 40953679 DOI: 10.1016/j.fitote.2025.106868
Abstract

Four undescribed protoberberine Isoquinoline Alkaloids (1-4), along with twenty-six known Alkaloids (5-30) were isolated from the aerial parts of Dactylicapnos lichiangensis. The structures and absolute configurations of 1-4 were established through comprehensive spectroscopic analysis and quantum chemical calculations. Compounds 1, 2 and 4 were evaluated for their anti-inflammatory activity. In vitro assays showed dose-dependent inhibition of nitric oxide production in LPS-stimulated macrophages, and significant suppression of TNF-α and IL-6 secretion.

Keywords
Anti-inflammatory activity; Dactylicapnos lichiangensis; Isoquinoline alkaloids; Papaveraceae.
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