Histone Deacetylase Inhibitor Panobinostat Augments the Antitumor Efficacy of Bromodomain Inhibitor JQ1 by Hijacking Mechanisms of Apoptosis in Head Neck Squamous Cell Carcinoma

  • Cell Biochem Biophys. 2025 Oct 31. doi: 10.1007/s12013-025-01941-w.
Xingyu Feng  1  2 ,  Xinghong Huang  3 ,  Shuangyue Zhang  1 ,  Meng Wu  1 ,  Wubi Zhou  4 ,  Jin Fang  1 ,  Cairong Dai  1 ,  Wei Zhang  5  6  7
Affiliations
  • 1. Department of Oral and Maxillofacial Surgery, The Affiliated Huaian No People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu Province, China.
  • 2. Department of Central Laboratory, Nanjing Medical University, The Affiliated Huaian No.1 People's Hospital, Huaian, 223300, Jiangsu Province, China.
  • 3. Department of Radiology, Nanjing Medical University, The Affiliated Huaian No.1 People's Hospital, Huaian, 223300, Jiangsu Province, China.
  • 4. Department of Pathology, Nanjing Medical University, The Affiliated Huaian No.1 People's Hospital, Huaian, 223300, Jiangsu Province, China.
  • 5. Department of Oral and Maxillofacial Surgery, The Affiliated Huaian No People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu Province, China. [email protected].
  • 6. Department of Central Laboratory, Nanjing Medical University, The Affiliated Huaian No.1 People's Hospital, Huaian, 223300, Jiangsu Province, China. [email protected].
  • 7. The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine Nanjing Medical University, Jiangsu, China. [email protected].
PMID: 41171581 DOI: 10.1007/s12013-025-01941-w
Keywords
Apoptosis; BRD4; HNSCC; JQ1; Panobinostat; Synergistic drug combination.
Products