KIF21B, Ubiquitinated by TRIM3, Exerts Oncogenic Role in T-Cell Acute Lymphoblastic Leukemia by Activating Wnt/β-Catenin Pathway

  • Cancers (Basel). 2026 Apr 22;18(9):1327. doi: 10.3390/cancers18091327.
Yu Sun  1 ,  Yuhao Xu  1 ,  Chao Lu  1
Affiliations
  • 1. Department of Pediatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
PMID: 42122124 DOI: 10.3390/cancers18091327
Abstract

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) remains a therapeutic challenge, with approximately 20% of patients experiencing relapse due to a limited understanding of molecular drivers [...].

Keywords
KIF21B; Wnt/β-catenin signaling; acute lymphoblastic leukemia; prognosis; ubiquitination.
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