Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells

  • Science. 1983 Feb 25;219(4587):987-8. doi: 10.1126/science.6297010.
W M Canning ,  B N Fields
PMID: 6297010 DOI: 10.1126/science.6297010
Abstract

Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during Infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent Infection.

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