Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia

  • Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46. doi: 10.1016/0278-5846(94)90065-5.
M Kuniyoshi  1 ,  J Nakamura ,  C Miura ,  K Inanaga
Affiliations
  • 1. Chikusuikai Hospital, Chikusuikai Institute for Neuroinformation, Yame-city, Japan.
PMID: 7516085 DOI: 10.1016/0278-5846(94)90065-5
Abstract

1. Setiptiline maleate was administered to schizophrenic patients with the object of improving their negative symptoms. 2. Moderate improvements were observed in 58% of the treated patients, thus usefulness of this drug was demonstrated. 3. There was no aggravation of symptoms, and side effects were minor. 4. Measurements of plasma monoamine metabolites showed a tendency of MHPG to decrease and a significant decrease in 5-HIAA, but no change in the level of HVA was observed, suggesting a relationship between the negative symptoms and noradrenaline and/or serotonin systems.

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