Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

  • J Antibiot (Tokyo). 1993 Jul;46(7):1082-8. doi: 10.7164/antibiotics.46.1082.
F Mayerl  1 ,  Q Gao ,  S Huang ,  S E Klohr ,  J A Matson ,  D R Gustavson ,  D M Pirnik ,  R L Berry ,  C Fairchild ,  W C Rose
Affiliations
  • 1. Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492.
PMID: 8360103 DOI: 10.7164/antibiotics.46.1082
Abstract

Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.

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