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Cat. No.: HY-119784

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Eupenifeldin

Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia.

For research use only. We do not sell to patients.

CAS No.: 151803-45-1
Formula: C₃₃H₄₀O₇
Molecular Weight:548.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Eupenifeldin Chemical Structure

CAS No.: 151803-45-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	30.6 nM Compound: 4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 26651221]
A549	IC₅₀	30.6 x 10^-3 μM Compound: 4	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 26651221]
H4	IC₅₀	130 nM Compound: 4	Antiproliferative activity against human H4 cells after 48 hrs by MTT assay Antiproliferative activity against human H4 cells after 48 hrs by MTT assay	[PMID: 26651221]
H4	IC₅₀	130 x 10^-3 μM Compound: 4	Antiproliferative activity against human H4 cells after 48 hrs by MTT assay Antiproliferative activity against human H4 cells after 48 hrs by MTT assay	[PMID: 26651221]
HCT-116	IC₅₀	31.2 nM Compound: 4	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 26651221]
HCT-116	IC₅₀	31.2 x 10^-3 μM Compound: 4	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 26651221]
HeLa	IC₅₀	8.2 nM Compound: 4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26651221]
HeLa	IC₅₀	8.2 x 10^-3 μM Compound: 4	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26651221]
OVCAR-3	IC₅₀	9.7 nM Compound: Eup	Cytotoxicity against human OVCAR-3 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OVCAR-3 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 37643353]
OVCAR-5	IC₅₀	11 nM Compound: Eup	Cytotoxicity against human OVCAR-5 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OVCAR-5 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 37643353]
OVCAR-8	IC₅₀	12 nM Compound: Eup	Cytotoxicity against human OVCAR-8 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OVCAR-8 cells assessed as inhibition of cell growth for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 37643353]
SH-SY5Y	IC₅₀	80 nM Compound: 4	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 26651221]
SH-SY5Y	IC₅₀	80 x 10^-3 μM Compound: 4	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 26651221]
T-24	IC₅₀	12.5 nM Compound: 4	Antiproliferative activity against human T24 cells after 48 hrs by MTT assay Antiproliferative activity against human T24 cells after 48 hrs by MTT assay	[PMID: 26651221]
T-24	IC₅₀	12.5 x 10^-3 μM Compound: 4	Antiproliferative activity against human T24 cells after 48 hrs by MTT assay Antiproliferative activity against human T24 cells after 48 hrs by MTT assay	[PMID: 26651221]
U-251	IC₅₀	100 nM Compound: 4	Antiproliferative activity against human U251 cells after 48 hrs by MTT assay Antiproliferative activity against human U251 cells after 48 hrs by MTT assay	[PMID: 26651221]
U-251	IC₅₀	100 x 10^-3 μM Compound: 4	Antiproliferative activity against human U251 cells after 48 hrs by MTT assay Antiproliferative activity against human U251 cells after 48 hrs by MTT assay	[PMID: 26651221]

Chemical Information

CAS No. 151803-45-1
Molecular Weight 548.67
Formula C₃₃H₄₀O₇
SMILES

OC1=CC2=C(C[C@@]3([C@@](C)([C@H](C[C@@]4(CC5=C(O[C@]4(C/C=C/C(C)(C3)C)C)C=C(C(C=C5C)=O)O)[H])O)O2)[H])C(C)=CC1=O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Eupenicillium brefeldianum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mayerl F, et al. Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum. J Antibiot (Tokyo). 1993;46(7):1082-1088. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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