Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata

  • J Nat Prod. 1993 Jan;56(1):22-9. doi: 10.1021/np50091a004.
L Z Lin  1 ,  H L Shieh ,  C K Angerhofer ,  J M Pezzuto ,  G A Cordell ,  L Xue ,  M E Johnson ,  N Ruangrungsi
Affiliations
  • 1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
PMID: 8450318 DOI: 10.1021/np50091a004
Abstract

An alkaloid extract derived from the roots of Cyclea barbata demonstrated cytotoxic and antimalarial activities, and five Bisbenzylisoquinoline Alkaloids, (+)-tetrandrine [1], (-)-limacine [2], (+)-thalrugosine [3], (+)-homoaromoline [4], and (-)-cycleapeltine [5], were isolated as the active principles. The complete and unambiguous assignments of the 1H- and 13C-nmr data of these substances were made by 1D and 2D nmr techniques (COSY, phase-sensitive ROESY, HETCOR, and FLOCK).